PHN患者脑代谢改变及其与认知损害相关性的MRS研究
Magnetic Resonance Spectroscopy Study on Brain Metabolic Changes and Their Correlation with Cognitive Impair-ment in Patients with Postherpetic Neuralgia
赵敏 1胡鑫 1刘雨茜 1王晶 1任福欣 1高飞 1赵斌1
作者信息
- 1. 山东第一医科大学附属省立医院医学影像科 山东 济南 250021
- 折叠
摘要
目的 探讨PHN患者的神经递质水平及其与认知之间的关系.方法 选取 25 例PHN患者和 25 例健康志愿者,评估所有参与者的认知功能,并检测其ACC和LINS脑区的GABA、GSH和Glu水平.结果 1)在PHN组中,ACC脑区的GABA水平降低,Glu水平升高,LINS脑区的Glu水平也升高;2)PHN组中,ACC脑区存在兴奋/抑制(E/I)失衡,且与信息处理速度相关;3)PHN组中,ACC和LINS脑区的Glu/GSH比值升高.结论 PHN患者存在GABA能系统和Glu能系统紊乱,以及E/I失衡和氧化还原失衡,这可能是导致PHN患者认知损害的潜在代谢因素.
Abstract
Objective This study aims to explore the correlation between neurotransmitter levels and cognitive functioning in individuals suffering from postherpetic neuralgia(PHN).Methods This study included 25 patients with PHN and 25 healthy volunteers.The cognitive function of all participants was assessed.The levels of GABA,GSH,and Glu in the anterior cingulate cortex(ACC)and the left insular cortex(LINS)were measured in the participants.Results 1)Reduced GABA levels and el-evated Glu levels were observed in the ACC of PHN group,with similarly increased Glu levels in the LINS.2)E/I intheACCof PHN grou pwas found to be associated with information processing speed.3)Elevated Glu/GSH were identified in both the ACC and LINS of PHN group.Conclusion The disruption of the GABAergic and glutamatergic systems within cognitive-related brain regions and the resulting E/I imbalance,as well as the redox imbalance,may be the metabolic factors contributing to cogni-tive impairment in patients with PHN.
关键词
带状疱疹后神经痛/脑代谢改变/认知损害/磁共振波谱Key words
Postherpetic Neuralgia/Brain Metabolic/Cognitive Impairment/Magnetic Resonance Spectroscopy引用本文复制引用
基金项目
山东省"泰山学者"建设工程项目(tsqn201812147)
山东省自然科学基金(ZR2021MH030)
山东第一医科大学"学术提升计划"项目(2019QL023)
出版年
2024
NETL
NSTL
维普
万方数据