摘要
目的 探讨利用MRS技术分析偏头痛患者大脑中的神经递质变化及其与认知、情绪改变的关系.方法 选取 31 例偏头痛(MA)患者为MA组,28 例健康受试者作为对照组.使用MRS分析前扣带回皮层(ACC)、小脑齿状核(DN)及左侧岛叶(LINS)的γ氨基丁酸(GABA)、谷氨酸(Glu)和谷胱甘肽(GSH)水平的变化,并观察其与认知、情绪及偏头痛特征的相关性.结果 与对照组比较,MA组表现出认知损害和焦虑症状;ACC中GSH水平增高(P =0.010),DN中GABA(P =0.043)和LINS中GABA(P =0.029)水平降低;DN中GABA与连线试验呈负相关(r =-0.542,P =0.002),LINS中GABA与MSQ(r =-0.441,P =0.017)、PHQ-9(r =-0.400,P =0.031)呈负相关.结论 本文为偏头痛患者认知、情绪变化的分析提供了新的视角.
Abstract
Objective This study aims to use MRS technology to investigate the changes in neurotransmitters in the brain of migraine patients and their relationship with cognitive and emotional changes.Methods Thirty-one migraine patients were selected as MA group and 28 healthy subjects as control group.Using MRS,we analyzed the changes of gamma-aminobutyric acid(GABA),glutamic acid(Glu)and glutathione(GSH)levels in anterior cingulate cortex(ACC),cerebellar dentate nucleus(DN)and left insula(LINS),and then,observed their correlation with cognitive performance,mood and migraine char-acteristics in migraine patients.Results Compared with the normal group,the MA group showed cognitive decline and anxiety increased;GSH level increased in ACC(P=0.010),GABA level decreased in DN(P=0.043)and LINS(P=0.029).In DN,GABA was negatively correlated with TMT_A(r=-0.542,P=0.002),while,in LINS,GABA was negatively correlated with MSQ(r=-0.441,P=0.017)and PHQ-9(r=-0.400,P=0.031).Conclusion This study provides a new perspective for the analy-sis of cognitive and emotional changes in migraine patients.
基金项目
山东省"泰山学者"建设工程项目(tsqn201812147)
山东省自然科学基金(ZR2021MH030)
山东第一医科大学"学术提升计划"项目(2019QL023)
NETL
NSTL
维普
万方数据