超声"萤火虫"成像对乳腺癌诊断价值的Meta分析
Ultrasound MicroPure imaging in diagnosis ofbreast cancer:A Meta-analysis
吴凤 1李阳 1王兵 1靳鹏1
作者信息
- 1. 蚌埠医学院第一附属医院超声医学科 安徽 蚌埠 233004
- 折叠
摘要
目的 用Meta分析评价超声"萤火虫"成像对乳腺癌的诊断价值.方法 检索PubMed、Cochrane、知网、万方等数据库中的相关文献并根据纳入标准严格进行文献筛选及质量评价.采用Meta-Desc及Stata 16.0 统计软件,检验异质情况并选择相应效应模型,获得敏感度、特异度及似然比的均值及 95%可信区间,绘制SROC曲线并计算曲线下面积,最后进行偏倚分析.结果 共纳入 18 篇文献,共 1647 个病例,1807 个病灶.由于存在非阈值效应引起的异质性,固采用随机效应模型合并效应量,合并敏感度、特异度及SROC曲线下面积分别为 83.00%(78.00%～87.00%),86.00%(81.00%～90.00%),0.91(0.88～0.93);合并诊断比值比(DOR)为 29.00(17.00～51.00).纳入文献较稳定,无明显发表偏倚(P=0.48>0.05).结论 Meta分析表明,超声"萤火虫"成像诊断乳腺癌的敏感度、特异度及准确率均较高,具有较高的临床应用价值.
Abstract
Objective To evaluate the diagnosticvalue of ultrasound MicroPure imaging in breast cancer by Meta analysis.Methods The databases including PubMed,EMBASE,Web of science,Cochrane Library,China National Knowledge Infra-structure(CNKI),Wanfang Data,CBM and VIP were searched comprehensively and screened respectively for the related articles from establishment to March 2022.The quality evaluation of the included articles was performed by QUADAS-2 which was used for judgement of the risk of bias and,the feature information was appraised and extracted.Simultaneously,the comprehensive evaluation was applied by Meta-Disc and Stata 16.0 statistical software.First of all,the heterogeneity was estimated and the corre-sponding effect model was selected,and then the mean value of sensitivity,specificity and likelihood ratio and 95%confidence in-terval were obtained,the area under the curve(AUC)of summary receive operating characteristic(SROC)was calculated,and fi-nally the bias analysis was carried out.Results Including 18 articles,the studies had a total of 1647 cases and 1807 lesions.There was heterogeneity caused by non-threshold effect in the included studies.The random effects model analysis showed that the mean sensitivity and confidence interval(95%)was 83.00%(78.00%～87.00%),the mean specificity was 86.00%(81.00%～90.00%),and AUC was 0.91(0.88～0.93).The combined diagnostic odds ratio(DOR)was significant 29.00(17.00～51.00).The included articles were stable and the publication bias was not statistically significant(P=0.48>0.05).Conclusion Meta analysis indicates that ultrasound MicroPure imaging technology has not only higher sensitivity,but also higher specificity and accuracy in the diagnosis of breast cancer,which can provide valuable information particularly on breast cancer with calcification.
关键词
乳腺肿瘤/超声检查/"萤火虫"成像/Meta分析Key words
Breast neoplasms/Ultrasonography/Fireflies imaging/Meta-analysis引用本文复制引用
基金项目
安徽省教育厅重点项目(KJ2020A0582)
蚌埠医学院自然科学研究重点项目(BYKY2019113ZD)
出版年
2024
NETL
NSTL
万方数据