基于MRI影像组学列线图术前预测宫颈癌患者淋巴结转移的价值
Preoperative prediction of lymph node metastasis in cervical cancer patients based on MRI imaging omics column chart
方莹 1徐敏 2李艳 3杨昭 2李阳 2邹梦梦 2谢宗玉2
作者信息
- 1. 蚌埠医科大学第一附属医院神经电生理科 安徽 蚌埠 233000
- 2. 蚌埠医科大学第一附属医院放射科 安徽 蚌埠 233000
- 3. 蚌埠医科大学第一附属医院妇瘤科 安徽 蚌埠 233000
- 折叠
摘要
目的 探讨MRI影像组学评分结合血液学参数的列线图模型对术前宫颈癌患者淋巴结转移的预测价值.方法 选取 189例经手术病理证实的宫颈癌患者,以 7:3的比例随机分为训练集 132例和验证集 57例.均术前接受MRI检查,于矢状位T2WI和对比增强T1WI沿肿瘤边缘逐层勾画三维感兴趣区域(VOI),并提取影像组学特征.通过最小绝对收缩与选择算子(LASSO)回归分析对提取的纹理特征进行初步筛选,并利用支持向量机(SVM)构建影像组学模型.同时,采用单-多因素逻辑回归构建影像组学列线图.使用ROC曲线来评估影像组学模型、临床模型和影像组学列线图的预测能力,并通过决策曲线分析(DCA)来评估影像组学列线图在临床应用中的价值.结果 影像组学列线图模型诊断性能最佳,优于临床模型、影像组学模型及血液学模型.校准曲线和Hosmer-Lemeshow检验结果提示列线图预测宫颈癌淋巴结转移与实际结果间一致性良好.结论 基于MRI影像组学列线图可高效准确的预测宫颈癌患者淋巴结转移情况,有较高应用价值.
Abstract
Objective To explore the predictive value of the nomogram model of MRI imaging omics score combined with he-matological parameters for lymph node metastasis in preoperative cervical cancer patients.Methods 189 patients with cervical cancer confirmed by surgical pathology were selected and randomly divided into training set(132 cases)and validation set(57 cases)at a ratio of 7:3.All selected candidates underwent MRI preoperative examination,delineated three-dimensional regions of interest along the edge of the tumor in sagittal T2WI andcontrast-enhanced T1WI,and imaging omics features were extracted.The extracted texture features were initially selected by minimum absolute shrinkage and selection operator regression analysis,and the imaging omics model was constructed using the support vector machine.Meanwhile,single-multifactor logistic regression was used to construct the imaging omics nomogram.ROC curves were used to evaluate the predictive ability of imaging omics model,clinical model and imaging omics nomogram,and to evaluate the value of imaging omics nomogram in clinical application by decision curve analysis.Results The imaging nomogram model had the best diagnostic performance than the clinical model,imaging model and hematology model.The results of calibration curve and Hosmer-Lemeshow test suggested good agreement be-tween cervical lymph node metastasis and the actual results.Conclusion Based on MRI imaging omics nomogram can effi-ciently and accurately predict the lymph node metastasis in cervical cancer patients,which has high application value.
关键词
宫颈癌/淋巴结/磁共振成像/影像组学/列线图Key words
Cervical cancer/Lymph node/Magnetic resonance imaging/Imaging omics/Nomogram引用本文复制引用
基金项目
安徽省自然科学基金(2008085MC69)
出版年
2024
NETL
NSTL
万方数据