基于MRI平扫及增强扫描分析高血压对肾透明细胞癌的影响
The effect of hypertension on clear cell carcinoma of the kidney based on the analysis of non-contrast MRI scan and contrast-enhanced scanning
王长军 1刘玉红 1周文文 1郭凌飞2
作者信息
- 1. 山东省济南市济阳区人民医院影像科 山东 济南 251400
- 2. 山东第一医科大学附属省立医院医学影像科 山东 济南 250021
- 折叠
摘要
目的 分析合并高血压与不合并高血压的肾透明细胞癌的MRI 表现,探讨高血压对肾透明细胞癌进展的影响.方法 选取经手术病理证实的 213 例肾透明细胞癌的术前MR图像,对其临床资料及MR图像进行分析.利用ITK SNAP 3.8 软件在皮质期、髓质期、延迟期三期相分别对病变逐层勾画,选择信号值最高的一个期相定为病变增强扫描最明显期相.将合并 3 年以上高血压病史的病例纳入高血压组、从未诊断过高血压纳入非高血压组,对两组病例临床资料及 MRI 特征进行比较分析.结果 高血压组强化最明显期相更倾向出现在皮质期,非高血压组倾向出现在髓质期,两组差异有统计学意义(P<0.05);高血压组年龄较大,男性较多,差异有统计学意义(P<0.05).肿瘤的Fuhrman分级中,非高血压组的Ⅰ级肿瘤更多,差异有统计学意义(P=0.044).两组就诊原因、肿瘤大小等其他临床、影像特征差异无统计学意义(P>0.05).结论 在肾透明细胞癌患者中,合并高血压的肾透明细胞癌强化最明显的期相出现更早,提示其可能含有更丰富的微血管.
Abstract
Objective By analyzing the differences in the MRI findings of clear cell renal cell carcinoma(CCRCC)with and without hypertension,we explored the effect of hypertension on CCRCC progression.Methods We retrospectively collected and analyzed the MRI images and clinical data of the 110 patients confirmed by surgery and pathology.ITK SNAP 3.8 software was used to delineate the lesions layer by layer.The delineated sequences were cortical phase,medullary phase and excretion phase,and the sequence with the highest signal value was selected as the most obvious phase of enhanced scanning.Patients with a his-tory of hypertension were included in the hypertension group and never diagnosed with hypertension as the non-hypertension group.The clinical data and MRI characteristics were compared and analyzed between the two groups.Results The most obvi-ous phase of enhancement was more likely to occur in the cortical phase in hypertensive group and in the medullary phase in non-hypertensive group.There was a statistical difference(P<0.05).The patients of hypertension group were older and tended to males than that of non-hypertension group(P<0.05).In the Fuhrman grade of tumors,there were more grade I tumors in the non-hypertensive group(P=0.044).Other clinical traits,such as the pathologicaland imaging characteristics,tumor size,and etc.had no significant differences between the two groups(P>0.05).Conclusion Among CCRCC patients,the most obvious phase of CCRCC enhancement with hypertension appears earlier,suggesting that it may contain more abundant microvessels.
关键词
肾透明细胞癌/磁共振成像/高血压Key words
Clear cell renal cell carcinoma/Magnetic resonance imaging/Hypertension引用本文复制引用
基金项目
山东省自然科学基金面上项目(ZR2020MH288)
出版年
2024
NETL
NSTL
万方数据