摘要
目的 探讨磁共振DWI与血清肿瘤标志物对妇科良恶性肿瘤的评价.方法 选取本院诊治的 168 例妇科肿瘤患者资料,根据穿刺或手术病理检查分为良性组 92 例、恶性组 76 例,并根据病理分期将恶性组分为Ⅰ期(32 例)、Ⅱ期(18 例)、Ⅲ期(15 例)、Ⅳ期(11 例).对比表观扩散系数(ADC)、糖类抗原 153(CA153)、糖类抗原 125(CA125)、癌胚抗原(CEA).结果 恶性组的ADC低于良性组,而CA153、CA125、CEA高于良性组,差异有统计学意义(P<0.05).Ⅳ期患者的ADC分别低于Ⅰ期、Ⅱ期、Ⅲ期,而CA153、CA125、CEA高于Ⅰ期、Ⅱ期、Ⅲ期,差异有统计学意义(P<0.05).受试者工作特征曲线(ROC)分析显示ADC、CA153、CA125、CEA及四项联合诊断妇科良恶性肿瘤的AUC值分别为 0.842、0.811、0.848、0.772、0.909,各项预测效能比较差异有统计学意义(P<0.05).结论 DWI联合血清肿瘤标志物鉴别诊断妇科良恶性肿瘤具有较高的效能.
Abstract
Objective To explore the evaluation of magnetic resonance DWI and serum tumor markers in gynecological be-nign and malignant tumors.Methods Data of 168 gynecological tumor patients treated in our hospital were selected.Those pa-tients were divided into benign group(92 cases)and malignant group(76 cases)according to puncture or surgical pathological examination,and the patients in malignant group were further divided into stage Ⅰ(n=32 cases),stage Ⅱ(n=18 cases),stage Ⅲ(n=15 cases),and stage Ⅳ(n=11 cases)according to pathological stage.The apparent diffusion coefficient(ADC),carbo-hydrate antigen 153(CA153),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)were compared.Re-sults The ADC of the malignant group was lower than that of the benign group,while,the levels of CA153,CA125,and CEA were higher than those of the benign group(P<0.05).The ADC of stage Ⅳ patients was higher than that of stage Ⅰ,Ⅱ,and Ⅲ,respectively,while,CA153,CA125,and CEA were lower than those of stage Ⅰ,Ⅱ,and Ⅲ(P<0.05).ROC curve analysis showed that the AUC values of ADC,CA153,CA125,CEA and the combined diagnosis of benign and malignant gynecological tumors were 0.842,0.811,0.848,0.772,0.909,respectively(P<0.05).Conclusion DWI combined with serum tumor mark-ers is effective in differentiating benign and malignant gynecological tumors.
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