多模态超声检查特征对乳腺癌Ki-67、CMTM6表达的预测价值
Predictive value of multimodal ultrasound characteristics on Ki-67 and CMTM6 expression in breast cancer
仓庆 1叶新华 2张爱华1
作者信息
- 1. 江苏大学附属句容医院超声科 江苏 镇江 212400
- 2. 南京医科大学第一附属医院超声科 江苏 南京 210029
- 折叠
摘要
目的 探讨多模态超声检查特征对乳腺癌Ki-67、趋化素样因子MARVEL跨膜结构域包含 6(CMTM6)表达的预测价值.方法 选取接受手术治疗及病理证实的 145 例乳腺癌患者,术前进行常规超声检查、剪切波弹性成像(SWE)和超声造影(CEUS)检查,免疫组织化学法检测Ki-67、CMTM6 的表达.多因素logistic回归分析多模态超声检查特征对 Ki-67、CMTM6 表达的预测价值.结果 乳腺癌组织 Ki-67、CMTM6 表达阳性率分别为 90.34%(131/145)、88.97%(129/145),均高于癌旁正常乳腺组织 9.66%(14/145)、11.03%(16/145),差异有统计学意义(χ2=198.7、199.1,P均<0.001).常规超声检查肿块形态、肿块边界和有无微钙化与乳腺癌Ki-67、CMTM6 表达差异均有统计学意义(P均<0.05).SWE征象中硬环征、黑洞征与乳腺癌Ki-67、CMTM6 表达差异均有统计学意义(P均<0.05).CEUS特征以早增强、晚消退灌注与乳腺癌Ki-67、CMTM6 表达差异均有统计学意义(P均<0.05).logistic回归分析显示,肿块形态不规则、边界不清楚、微钙化、硬环征、黑洞征及早增强、晚消退灌注是乳腺癌Ki-67、CMTM6 阳性表达的独立预测因素.结论 多模态超声检查特征可用于预测乳腺癌Ki-67、CMTM6 的表达,从而为乳腺癌的诊治提供依据.
Abstract
Objective To investigate the predictive value of multimodal ultrasound features for Ki-67 and chemokine like fac-tor MARVEL transmembrane domain containing 6(CMTM6)expression in breast cancer.Methods 145 breast cancer patients who received surgical treatment were examined by conventional ultrasound,shear wave elastography(SWE)and contrast-enhanced ultrasound(CEUS)before surgery.The expression of Ki-67 and CMTM6 was detected by immunohistochemistry.Multi-variate logistic regression analysis was used to analyze the predictive value of multimodal ultrasound features on Ki-67 and CMTM6 expression.Results The positive rates of Ki-67 and CMTM6 in breast cancer tissues were 90.34%(131/145)and 88.97%(129/145),respectively,which were higher than those in normal breast tissues adjacent to cancer 9.66%(14/145)and 11.03%(16/145)(χ2=198.7,199.1,P<0.001).The tumor shape,tumor boundary and microcalcification in conventional ultra-sound were related to the expression of Ki-67 and CMTM6 in breast cancer(all P<0.05).The hard ring sign and black hole sign in SWE were related to the expression of Ki-67 and CMTM6 in breast cancer(P<0.05).The early enhancement and late regres-sion perfusion of CEUS characteristics were related to the expression of Ki-67 and CMTM6 in breast cancer(P<0.05).Logistic re-gression analysis showed that irregular tumor shape,unclear boundary,microcalcification,hard ring sign,black hole sign,early enhancement and late regression perfusion were independent predictors of Ki-67 and CMTM6 positive expression in breast cancer.Conclusion Multimodal ultrasound features can be used to predict the expression of Ki-67 and CMTM6 in breast can-cer,which is helpful for the diagnosis and treatment of breast cancer.
关键词
乳腺癌/剪切波弹性成像/超声检查Key words
Breast cancer/Shear wave elastic imaging/Ultrasound引用本文复制引用
基金项目
江苏省句容市科技计划(ZA42216)
江苏大学医教协同创新基金一般项目(JDYY2023038)
出版年
2024
NETL
NSTL
万方数据