MRI诊断Marchiafava-Bignami病的临床价值分析
Analysis of the value of MRI in the diagnosis of Marchiafava-Bignami disease
裴磊 1张发2
作者信息
- 1. 温州医科大学附属衢州医院 衢州市人民医院放射科 浙江 衢州 324000
- 2. 贵州省六枝特区人民医院放射科 贵州 六盘水 553000
- 折叠
摘要
目的 探讨Marchiafava-Bignami 病(MBD)MRI检查的应用价值.方法 选取MBD患者 28 例,行MRI检查,分析胼胝体区及胼胝体外病灶的MRI特征.结果 28 例患者中急性型 17 例,亚急性型 6 例,慢性型 5 例.17 例急性型MBD中 13 例表现为胼胝体肿胀,以胼胝体膝部、体部较为明显,病灶为两侧对称分布,边界不清楚,呈T1WI低信号、T2WI 和FLAIR序列高信号.亚急性型MBD中 5 例表现为胼胝体轻度肿胀,3 例正中矢状位可见胼胝体呈"三明治征"改变,即胼胝体中层T1WI低信号、T2WI高信号,上下两层信号相对正常.慢性型MBD中有 5 例胼胝体体积缩小和轻中度萎缩,病灶边界较清楚.28例患者中有 16例表现为DWI序列高信号,ADC值可降低或稍高.28例患者中 21例出现胼胝体以外病灶,分布以半卵圆中心和额顶叶脑白质区、前联合、小脑中脚为主,信号改变同胼胝体内病变一致.结论 Marchiafava-Bignami病可发生在胼胝体和胼胝体外,病灶大多对称分布,常规MRI结合DWI诊断MBD临床价值高.
Abstract
Objective To investigate the clinical manifestations and MRI imaging features of Marchiafava-Bignami disease(MBD).Methods A retrospective study was conducted on 28 patients diagnosed with MBD,including clinical manifestations and imaging examinations and the morphological distribution characteristics and signal performance of the patients'corpus callo-sum area and extra-corpus callosum lesions were analyzed.Results Among the 28 patients,17 had acute MBD,6 had sub-acute MBD,and 5 had chronic MBD.13 of the 17 acute MBD cases showed swelling of the corpus callosum,which was more ob-vious in the knee and body of the corpus callosum,and the lesions were symmetrically distributed on both sides with unclear bor-ders,showing low signal in T1WI and high signal in T2WI and FLAIR sequences.Five cases of subacute MBD showed mild swell-ing of the corpus callosum,and three cases showed a"sandwich sign"change of the corpus callosum in the median sagittal view,i.e.low signal in T1WI and high signal in T2WI in the middle layer of the corpus callosum,with relatively normal signal in the up-per and lower layers.In the chronic type of MBD,5 cases showed reduced volume and mild to moderate atrophy of the corpus cal-losum,with clear boundaries.16 of 28 patients showed DWI high signal,while the rest showed slightly high or equal signal,and ADC values could be decreased or increased.21 of 28 patients showed extra-callosal lesions,mainly in the centrum semiovale and frontoparietal white matter,anterior commissure,and mid-cerebellar peduncle,with signal changes consistent with those in the corpus callosum.The signal changes were consistent with the intracallosal lesions.Conclusion MBD can occur in both the cor-pus callosum and extra-corpus callosum,and the lesions are mostly symmetrically distributed.
关键词
胼胝体变性/酒精性脑病/磁共振成像Key words
Corpus callosum degeneration/Alcoholic encephalopathy/Magnetic resonance imaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据