CT直方图分析预测十二指肠乳头癌淋巴结转移的临床应用价值
Clinical application of CT histogram analysis in predicting lymph node metastasis in duodenal papillary carcinoma
谢群 1毕蕾 2张龄艺 1徐鸿志 3蔡世峰1
作者信息
- 1. 山东第一医科大学附属省立医院医学影像科 山东 济南 250021
- 2. 山东第一医科大学附属省立医院医学影像科 山东 济南 250021;山东省临沂市人民医院放射科 山东 临沂 276000
- 3. 山东省临沂市人民医院超声医学科 山东 临沂 276000
- 折叠
摘要
目的 探讨CT直方图分析预测十二指肠乳头癌(DPC)淋巴结转移的临床应用价值.方法 选取 30 例DPC患者资料,所有患者术前均行CT增强扫描.采用深睿多模态科研平台对静脉期图像勾画感兴趣区(ROI)并提取直方图参数,进行单因素分析以评估淋巴结转移阳性组和阴性组之间的参数差异.利用Pearson或Spearman的相关性分析探讨变量与淋巴结转移之间的相关性.利用受试者工作特征(ROC)曲线分析评价直方图参数对于DPC淋巴结转移的诊断效能.结果 直方图参数中的均匀度、熵和方差在淋巴结转移阳性与阴性的比较均差异有统计学意义(P<0.05).在CT直方图参数中,均匀度在预测DPC淋巴结转移时达到最高ROC曲线下面积(AUC=0.886);当均匀度和肿瘤大小相结合或均匀度与癌胚抗原(CEA)相结合时,AUC=0.915;当均匀度、肿瘤大小及CEA相结合时为最高的AUC=0.938.结论 基于全病灶CT直方图分析可用于预测DPC的淋巴结转移,并且均匀度、肿瘤大小及CEA组合是区分DPC淋巴结转移的最佳选择.
Abstract
Objective To explore the clinical application value of CT histogram analysis in predicting lymph node metastasis in duodenal papilla carcinoma(DPC).Methods A retrospective analysis was conducted on the data of 30 patients with DPC,all of whom underwent preoperative contrast-enhanced CT scans.The Dr.Wise Multimodal Research Platform was used to delin-eate regions of interest on the venous phase images and extract histogram parameters.Univariate analysis was performed to evalu-ate the differences in parameters between the lymph node metastasis positive group and the negative group.Pearson or Spearman correlation analysis was used to explore the correlation between variables and lymph node metastasis.Logistic regression was used to find the optimal combination model.The receiver operating characteristic(ROC)curve was used to evaluate the diagnos-tic performance of histogram parameters for DPC lymph node metastasis.Results Histogram parameters including uniformity,entropy,and variance showed statistically significant differences between the lymph node metastasis positive group and the nega-tive group(P＜0.05).Among the CT histogram parameters,uniformity achieved the highest area under the ROC curve(AUC)in predicting lymph node metastasis of DPC,with a value of 0.886;when combined with tumor size or carcinoembryonic antigen(CEA),the AUC reached 0.915;the highest AUC of 0.938 was achieved when uniformity,tumor size,and CEA were com-bined.Conclusion CT histogram analysis based on the entire lesion can be used to predict lymph node metastasis of DPC,and the combination of uniformity,tumor size,and CEA is the optimal choice for distinguishing lymph node metastasis of DPC.
关键词
十二指肠乳头癌/直方图分析/淋巴结转移/体层摄影术,X线计算机Key words
Duodenal papilla carcinoma/Histogram analysis/Lymph node metastasis/Tomography,X-ray computed引用本文复制引用
出版年
2024
NETL
NSTL
万方数据