Studying and Researching Atherosclerosis from Oxidative Stress
ROS is the normal metabolic product of oxidation-reduction reaction.When the producing of ROS is faster than clearing,the excessive reactive oxygen cannot only injure body cells directly,but also lead to a series of pathophysiologic process though signal transduction system.Various oxide precursors can stimulate vascular cells to produce reactive oxygen species,which accelerate atherosclerosis formation and development.The antioxidants such as statins,probucol,have strongly anti-oxidative and anti-atherosclerosis effect and are the most promising drugs for the anti-oxidative therapy on coronary heart disease.
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