Objective To assess the value of contrast-enhanced MR angiography(CE-MRA)and dynamic susceptibility contrast perfusion-weighted imaging(DSC-PWI)using 3 T MR system with low dose and high concentration of gadolinium butoxide in patients with acute ischemic stroke(AIS).Methods Fifty patients with clinically suspected AIS were randomly divided into two groups of 25 patients.The routine concentration group underwent CE-MRA and DSC-PWI using 0.2 mL/kg of intravenous gadopentetate dimeglumine whereas the high concentration group were scanned using 0.06 mL/kg of intravenous gadolinium butoxide.The image quality score,signal intensity(SI)difference,vascular stenosis and ischemic penumbra were compared between the two groups.Results There was no significant difference in image quality scores between high(3.54±0.32)and conventional(3.44±0.58)concentration groups(t=0.752,P=0.457).The SI(448.57±180.93),signal-to-noise ratio(SNR,196.05±70.86)and contrast-to-noise ratio(CNR,183.32±68.08)at the bifurcation of the common carotid arteries in the high concentration group were not significantly(P＞0.05)different from those in the conventional concentration group(426.99±147.88,189.39±55.89,178.34±53.68).The SNR(254.61±81.03)and CNR(235.46±77.72)at the origins of the middle cerebral arteries in the high concentration group were significantly(P＜0.05)higher than those in the conventional concentration group(197.78±58.62,183.44±56.52)whereas there was no significant difference(P＞0.05)in the SI between the 2 groups(393.67±133.02,353.67±139.78).There was a strong consistency between the observers in the diagnosis of arterial stenosis on CE-MRA(κ=0.763,0.819)and ischemic penumbra on DSC-PWI(κ=0.84,0.883)between the two groups.Conclusion 3 T CE-MRA and DSC-PWI with low dose and high concentration contrast agent are feasible for assessing acute ischemic stroke.
维普
万方数据