关于多灶性肝癌诊疗的思考
Reflections on the diagnosis and treatment of multifocal hepatocellular carcinoma
张小晶 1金亮 1陶开山 1王琳1
作者信息
- 1. 空军军医大学西京医院肝胆外科,陕西西安 710032
- 折叠
摘要
多灶性肝癌在肝癌中的发生率较高,具有高侵袭性及高增殖性的特点,与患者预后不良密切相关.多灶性肝癌发生的相关因素较多,发病机制复杂,尚处于探索研究阶段.多灶性肝癌亚分期的研究已经有一定的成果,但由于其治疗选择的局限性,在临床实践中存在争议.越来越多的研究认为多灶性肝癌肝切除术是一种有效的治疗方式,具有较好的长期预后和更低的复发率和死亡率,但选择适宜手术对患者至关重要,对于不能一期手术切除的多灶性肝癌患者,根据其不同的表现形式选择最适宜的联合治疗方式.所以临床需要更加完善的评估模式来对多灶性肝癌患者进行分层研究,精准治疗,使更多患者获益.
Abstract
Multifocal hepatocellular carcinoma(HCC)has a high incidence in HCC,which is characterized by high invasiveness and high proliferation,and is closely related to poor prognosis of patients.There are many factors related to the occurrence of multifocal HCC,and the pathogenesis is complex,which is still in the exploratory research stage.The study of multifocal HCC substaging has achieved certain results,but it is controversial in clinical practice due to the limitations of its treatment options.More and more studies suggest that liver resection for multifocal HCC is an effective treatment,with better long-term prognosis and lower recurrence rate and mortality.However,it is very important to select surgery suitable for patients.For patients with multifocal HCC who cannot be treated with surgical resection in one stage,the most appropriate combination therapy should be selected according to their different manifestations.Therefore,a more complete evaluation model is needed in clinical practice to conduct stratified research for patients with multifocal HCC and achieve precise treatment to benefit more patients.
关键词
肝癌,多灶性/发生机制/临床分期/手术切除/经皮肝动脉灌注化疗栓塞术/射频消融术/免疫治疗Key words
hepatocellular carcinoma,multifocal/pathogenesis/clinical stage/surgical resection/transarterial chemoembolization/radio frequency ablation/immunotherapy引用本文复制引用
基金项目
国家自然科学基金面上项目(81770560)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据