三级淋巴结构:是否可以成为肝癌患者的希望?
Tertiary lymphatic structure:can it be the hope of patients with liver cancer?
王彦芳 1张潇剑 2贾巍力 1毛珍珍 1石文 1聂耶 1宋文杰3
作者信息
- 1. 空军军医大学西京医院肝胆外科,陕西西安 710032;西安医学院研究生院,陕西西安 710021
- 2. 西安医学院研究生院,陕西西安 710021
- 3. 空军军医大学西京医院肝胆外科,陕西西安 710032
- 折叠
摘要
三级淋巴结构(TLS)由肿瘤浸润淋巴细胞的聚集形成,该淋巴细胞由肿瘤微环境中的各种趋化因子或细胞因子驱动.TLS在许多癌症类型中形成,除少数例外,其在各种肿瘤的进展中起着关键作用,它们的存在预示着良好的预后,同时还与免疫治疗反应具有一定的相关性.大量研究表明,TLS对于其他各类肿瘤例如黑色素瘤、子宫内膜癌、胰腺癌、结直肠癌、非小细胞肺癌都有明显的预后积极作用.但是TLS在肝细胞癌(HCC)中的作用仍然存在争议,潜在的分子机制仍有待阐明.因此,本文探讨了 HCC的现状、TLS的形成机制、TLS与HCC患者预后之间的关系、TLS在建立和/或维持局部免疫反应中的潜在作用,以及这种理解如何指导治疗干预,希望为开发新型疗法提供新思路.
Abstract
Tertiary lymphoid structures(TLS)are formed by the aggregation of tumor-infiltrating lymphocytes driven by various chemokines or cytokines in the tumor microenvironment.TLS are formed in many cancer types,with few exceptions,and play a key role in the progression of various tumors.Their presence predicts a favorable prognosis and is correlated with immunotherapeutic response.A large number of studies have shown that TLS have a positive prognostic effect on other types of tumors,such as melanoma,endometrial cancer,pancreatic cancer,colorectal cancer,and non-small cell lung cancer.However,the role of TLS in hepatocellular carcinoma(HCC)remains controversial and the underlying molecular mechanisms remain to be elucidated.Therefore,this paper discusses the status of HCC,the mechanism of TLS formation,the relationship between TLS and the prognosis of HCC patients,the potential role of TLS in establishing and/or maintaining local immune responses,and how this understanding can guide therapeutic interventions,hoping to provide new ideas for the development of novel therapies.
关键词
肿瘤微环境/三级淋巴结构/肝细胞癌/免疫治疗Key words
tumor microenvironment/tertiary lymphoid structures/hepatocellular carcinoma/immunotherapy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据