Since the beginning of life,organisms have evolved continuously to adapt to changes in the external environment,including daily changes in light and temperature due to the rotation of the Earth.The body presents an endogenous and adaptable life process with a cycle of approximately 24 h,which is called circadian rhythm.Various physiological and psychological activities such as sleep-wake,body temperature,blood pressure,and hormone secretion show the characteristics of circadian rhythm,and the maintenance of these characteristics depends on the normal expression of clock genes in hypothalamic suprachiasmatic nucleus and various tissues and organs.A large number of studies have shown that normal expression of clock genes or circadian activities can maintain the metabolic homeostasis of the body,while mutations in clock genes or the disorder of circadian activities may lead to imbalanced metabolic homeostasis of the body and even cause various metabolism-related diseases.This paper reviews the relationship between circadian rhythm and glycolipid metabolism in the body and analyzes the possibility of targeting clock genes or rhythm regulation in the treatment of metabolism-related diseases.
维普
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