In recent years,stem cell transplantation has become an important research direction in the field of regenerative medicine,and mesenchymal stem cells(MSCs)have become one of the most potential candidates for stem cell transplantation and tissue engineering due to their unique biological characteristics.However,the biological characteristics of MSCs cultured in vitro will be changed,which significantly affects their efficacy and safety in clinical applications.The culture condition is considered to be one of the most important factors affecting the therapeutic effect of MSCs.Several studies have found that simulated microgravity environment can effectively maintain the main biological characteristics of MSCs,which is beneficial to solve the problem of the loss of stem cell characteristics during the expansion of MSCs in vitro.This paper summarizes and discusses the effects of simulated microgravity environment on the homing ability,tumorigenicity,immunomodulation,and multi-directional differentiation potential of MSCs,as well as the possibility of using simulated microgravity to culture MSCs for regenerative therapy.
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