Objective To investigate whether inflammatory markers can predict the prognosis of patients with primary biliary cholangitis(PBC).Methods A retrospective study was conducted to explore the correlation between inflammatory markers and liver function through Spearman correlation analysis.The optimal cut-off value of inflammatory markers was determined by X-tile software.The effects of each inflammatory marker on prognosis were compared by Log-rank test and their respective Kaplan-Meier curves were drawn,and finally the inflammatory markers affecting prognosis were further analyzed by Cox survival analysis.Results The gamma-glutamyl transpeptidase-to-platelet ratio(GPR)was an independent risk factor for the prognosis of PBC patients,and higher GPR(≥1.9)prompted a poor prognosis.Conclusion GPR level at baseline has a correlation with the histological stage and poor prognosis of PBC patients.GPR(≥1.9)can be utilized as an independent predictor to suggest negative prognosis of PBC patients.
维普
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