Objective To investigate the effect of metformin on long-term function after spinal internal fixation surgery in patients with type 2 diabetes mellitus(T2 DM).Methods Patients with T2 DM who underwent spinal internal fixation surgery in Department of Orthopedics,Xijing Hospital,Air Force Medical University from January 2011 to January 2022 were selected and divided into metformin group and insulin group according to the use of hypoglycemic drugs.Patients'medical records and evaluation data of quality of life,spinal function and pain were collected.T-test,one-way ANOVA,Mann-Whitney U test,Kruskal-Wallis H test,x2test and multiple linear regression analysis were used to compare and analyze the data.Results A total of 204 patients were included,including 108 patients(52.94％)in the metformin group and 96 patients(47.06％)in the insulin group.In the long-term functional evaluation after surgery,compared with insulin,the use of metformin significantly improved the scores in the dimension of physical functioning(75.14 vs 65.36,P＜0.05)and the scores in the dimension of general health(58.02 vs 48.08,P＜0.05)of patients in the Short Form 36 Health Survey,and Neck Disability Index or Oswestry Disability Index were significantly reduced(15.93 vs 23.16,P＜0.05).In addition,higher fasting blood glucose or postprandial blood glucose,more surgical segments and larger body mass index were risk factors for the long-term postoperative function(P＜0.05).In terms of surgical methods,compared with anterior cervical discectomy and fusion,posterior lumbar interbody fusion was a risk factor for long-term postoperative function(P＜0.05).Conclusion Compared with insulin,the use of metformin can effectively improve the long-term function after spinal internal fixation surgery in patients with T2DM.
关键词
二甲双胍/2型糖尿病/脊柱内固定手术/术后远期功能
Key words
metformin/type 2 diabetes/spinal internal fixation surgery/postoperative long-term function
维普
万方数据