Sirtuin 3(Sirt3)is a nicotinamide adenine dinucleotide-dependent deacetylatase that is mainly involved in mitochondrial metabolic processes such as energy synthesis,tricarboxylic acid cycling,and oxidative stress.More scientific studies have confirmed that Sirt3 has the functions of anti-oxidative stress,anti-apoptosis and maintenance of metabolic homeostasis,and plays an important role in energy metabolism,tumors,aging and other processes.Recent studies have found that in neurodegenerative diseases,Sirt3 activation can slow down or inhibit mitochondrial dysfunction,thus showing a significant neuroprotective effect.This paper reviews the protective role of Sirt3 in neurodegenerative diseases and its possible mechanisms.
关键词
Sirtuin3/阿尔茨海默症/帕金森病/亨廷顿病/肌萎缩侧索硬化症/多发性硬化症/中枢神经系统
Key words
Sirtuin3/Alzheimer's disease/Parkinson's disease/Huntington's disease/amyotrophic lateral sclerosis/multiple sclerosis/central nervous system
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