Phosgene is a representative of chocking chemical warfare agents,which is widely used in industrial production.Phosgene inhalation exposure mainly leads to acute lung injury(ALI),which is easy to progress to pulmonary edema and respiratory distress syndrome,with a high mortality rate.There is still a lack of effective treatment methods in the world.With highly differentiated potential,mesenchymal stem cells(MSC)can play a variety of biological functions such as immunomodulation,anti-inflammation,antioxidation,and injury repair,and are widely used in the fields of disease treatment and regenerative medicine.Recent studies have found that MSC mainly locates in lung tissue after transplantation and has strong targeting,which may have natural advantages in treatment of acute and chronic lung injury.This paper mainly expounds the biological function of MSC and its application in the treatment of lung diseases,and summarizes and prospects the study of MSC in phosgene-induced ALI,so as to provide a strong guarantee for national defense,military and national economic construction.
维普
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