18号染色体多体在恶性周围神经鞘膜瘤的诊断价值及其与临床病理特征的相关性分析
Diagnostic value of chromosome 18 polysomy in malignant peripheral nerve sheath tumors and its correlation with clinicopathological features
徐婉妮 1刘一雄 1范林妮1
作者信息
- 1. 空军军医大学西京医院病理科,消化系肿瘤整合防治全国重点实验室,陕西西安 710032
- 折叠
摘要
目的 探讨18号染色体多体在恶性周围神经鞘膜瘤(MPNST)的诊断价值及其与临床病理特征的相关性分析.方法 收集2010-2024年西京医院病理科诊断的37例MPNST,采用荧光原位杂交(FISH)技术进行检测,并总结其临床病理学特征及免疫表型.结果 37例患者中男性22例,女性15例,年龄4～78(平均37)岁.肿瘤平均大小为10.8 cm.MPNST最常见的原发部位为躯干(22/37).FISH结果示37例患者中10例(27.0％)存在18号染色体多体.统计学结果示18号染色体多体与高核分裂象(P=0.013)和肿瘤分级(P=0.005)呈正相关,且多见于头颈部(P=0.003).结论 在本研究中,FISH显示MPNST中存在18号染色体多体,这可能与肿瘤组织学形态更具侵袭性和分级更高有关,并为其与其他梭形细胞肉瘤的鉴别诊断提供了线索.
Abstract
Objective To investigate the diagnostic value of chromosome 18 polysomy in malignant peripheral nerve sheath tumors(MPNST)and its correlation with clinicopathological features.Methods A total of 37 cases of MPNST diagnosed in Department of Pathology,Xijing Hospital from 2010 to 2024 were collected.Fluorescence in situ hybridization(FISH)was used to detect MPNST,and the clinicopathological features and immunophenotypes were summarized.Results Among the 37 patients,22 were males and 15 were females,with a mean age of 37 years(range:4～78 years).The mean tumor size was 10.8 cm.The most common primary site of MPNST was in the trunk(22/37).FISH results showed that 10 out of 37 cases(27.0％)presented with chromosome 18 polysomy.The statistical results showed that chromosome 18 polysomy was positively correlated with high mitotic activity(P=0.013)and tumor grade(P=0.005),and was more common in the head and neck(P=0.003).Conclusion In this study,FISH reveals chromosome 18 polysomy in MPNST,which may be correlated with a more aggressive histological morphology and higher grade of the tumor.It also provides a clue for the differential diagnosis with other spindle cell sarcomas.
关键词
恶性周围神经鞘膜瘤/18号染色体多体/荧光原位杂交/基因重排Key words
malignant peripheral nerve sheath tumors/chromosome 18 polysomy/fluorescence in situ hybridization/gene rearrangement引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据