SHIP1在肿瘤发生发展及免疫调节中的作用
Role of SHIP1 in tumorigenesis,development and immune regulation
沈宇杰 1徐盈 1杨红 1李佳 1李远凤 1陈志浩 1冯忘忧 1陈紫均1
作者信息
- 1. 空军军医大学西京医院妇产科,陕西 西安 710032
- 折叠
摘要
含有SH2 区域的肌醇5′磷酸酶1(SHIP1)是一类主要但不完全表达在造血源性细胞胞质中的磷酸酶蛋白,属于肌醇 5′磷酸酶家族,是磷脂酰肌醇-3-激酶(PI3K)信号通路的重要负性调控因子.PI3K信号通路已被证明在肿瘤的发生发展中起作用,而SHIP1 作为磷酸肌醇信号通路的调节因子,是肿瘤发生发展和免疫调节中不容小觑的一环.本文旨在总结SHIP1 在肿瘤发生发展和免疫调节中的作用,以探寻肿瘤治疗新途径.
Abstract
The SH2-containing inositol 5'-phosphatase 1(SHIP1)is a kind of phosphatase proteins mainly but not completely expressed in the cytoplasm of hematopoietic cells.It belongs to the inositol 5'-phosphatase family and is an important negative regulator of phosphatidylinositol-3-kinase(PI3K)signal pathway.PI3K signal pathway has been proved to play a role in tumorigenesis and development.As a regulator of phosphoinositide signal pathway,SHIP1 plays an important role in tumorigenesis,development and immune regulation.The purpose of this review is to summarize the role of SHIP1 in tumorigenesis,development and immune regulation,in order to explore new ways of tumor treatment.
关键词
SH2区域的肌醇5′磷酸酶1/肿瘤/免疫调节Key words
SH2-containing inositol 5'-phosphatase 1/tumor/immune regulation引用本文复制引用
基金项目
国家自然科学基金(82172993)
陕西省自然科学基础研究计划项目(2022JQ-977)
出版年
2024
国家科技期刊平台
NSTL
万方数据