During the implementation of the Human Genome Project,massive and complicated genomic data are generated,and the genomic information of a single species is limited.Comparing the genomes of different organisms can reveal the rich information contained in the genome,and comparative genomics has developed in the process of genome sequence alignment and function disclosure.Comparative genomics can be used to predict the number,location,function,and expression mechanism of genes,and to analyze biological evolution,which is a powerful tool for annotating genome structure and function,and contributes to reveal the mystery of genetic variation and evolutionary development of life.In this paper,the development history,research content and core research methods of comparative genomics are reviewed through academic search of relevant biotechnology information databases,so as to provide guidance and help for further research on genomics.
关键词
比较基因组学/系统发生/单核苷酸多态性/溯祖理论
Key words
comparative genomics/phylogeny/single nucleotide polymorphism/coalescent theory
维普
万方数据