Objective To analyze the characteristics of brain functional connectivity gradient in patients with autism spectrum disorder(ASD)and typical controls(TC)based on the brain functional connectivity gradient analysis.Methods This study included 1 373 subjects(ASD/TC:684/689).Based on the resting-state functional magnetic resonance imaging of ASD group and TC group,the resting-state functional connectivity(RSFC)matrix was established.The affinity matrix was constructed according to RSFC matrix to calculate the brain functional connectivity gradient.Two-sample t test was used to compare the differences and changes of global index and local gradient score anomaly between ASD group and TC group.The correlation between brain networks with significant differences in statistical test results and scores of related scales was studied.Results The gradient explanation rate and gradient variability of the first gradient in ASD group were significantly lower than those in TC group(P＜0.05).The local gradient score anomaly in ASD group was mainly in default mode network and somatomotor network(P＜0.05),involving primary perceptual processing and advanced abstract cognition,and were negatively correlated with patient scale scores.Conclusion Abnormalities in the functional connectivity gradient of default mode network and somatomotor network in ASD patients may provide new insights to explore the etiological mechanisms of ASD.
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