Parkinson's disease(PD)is one of the most common neurodegenerative diseases,and its typical pathological changes include the formation of α-synuclein positive inclusion bodies in neurons and axons and the loss of dopaminergic neurons.The pathogenesis of PD is very complex,and no drug has been proven to have a definite therapeutic effect on PD.A large number of studies have proved that immune inflammation and mitochondrial dysfunction are closely related to the occurrence and development of PD.At the same time,in the drug development of PD,many good treatment strategies have been studied in clinical evaluation,but its complex pathogenesis and interaction of various pathological factors urgently require the development of biomarkers to provide a new direction for the early diagnosis of PD patients.The development of effective biomarkers will reduce the risk of PD,explore more effective disease treatment methods,and realize early intervention and treatment of PD.
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