摘要
特发性肺(间质)纤维化是一种原因不明的、进行性的、局限于肺部的弥漫性肺泡炎和肺泡结构紊乱,最终导致以肺纤维化伴蜂窝状改变为特征的疾病,肺功能测试显示限制性通气功能障碍和(或)换气障碍.由于其发病机制较为复杂,目前尚无有效的治疗措施,预后差,成为目前国内外的研究热点.近年来,在特发性肺纤维化的治疗方面取得一些进展,现从糖皮质激素、细胞因子、细胞因子拮抗剂、抗氧化治疗及中药等治疗方面进行综述.
Abstract
Idiopathic (interstitial) pulmonary fibrosis is a progressive diffuse pulmonary alveolitis and alveolar structural disruption of unknown cause and confined to lungs.It is characteristic of cellular lesions on top ofpulmonary fibrosis The pulmonary function test shows restrictive ventilatory dysfunction and ( or) air exchange disorder.Due to its complex pathogenesis,there is no effective treatment and the prognosis is poor, making it a research hotspot worldwide.In recent years, the treatment of idiopathic pulmonary fibrosis has made some progress.This article reviews glucocorticoids,cytokines,cytokine antagonists, anti - oxidatives, and Chinese medicine.
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