摘要
右美托咪定(Dex)是一种新型高选择性α2 肾上腺素能受体激动剂,具有多种药理特性,Dex除镇静、镇痛作用外,还能抑制交感神经兴奋性,增强迷走神经兴奋性,稳定血流动力学,为患者带来了很大益处,但还需根据不同的具体情况,选择合适的用药剂量,使其充分发挥临床优势.Dex通过激动脑干α2受体最密集的区域-蓝斑产生镇静作用,通过作用于脊髓后角α2受体,抑制疼痛信号的传导,产生镇痛效果.Dex在临床上的应用十分广泛,但对于临床使用剂量和使用时间等问题需要临床大量的数据得以证实,才能成为更安全可靠的临床药物.
Abstract
Dexmedetomidine(Dex) is a highly selective and specific α2-adrenoreceptor agonist,which has many pharmacological properties.Dex can reduce the sensitivity of the sympathetic nervous system and enhance the excitability of the vagus nerve so as to provide excellent hemodynamics besides sedative and analgesic effect.Meanwhile it produces a lot of benefits for patients,and we should choose right doses according to the specific circumstances and fully develop its clinical advantages.Dex can produce sedative effect by exciting locus coeruleus of brainstem that is the most densely distributed region of α2 receptor.Dex can also inhibit the transmission of pain signals and provide the analgesic effect by combining with α2 receptor of spinal cord posterior horn.It is widely used in clinical,but it still needs large amounts of clinical data to validate the clinical dosage and time,to make it become a more safe and reliable clinical drug.
NETL
NSTL
维普
万方数据