摘要
目的:制备美洛昔康醇质体凝胶.方法:通过正交设计优选出美洛昔康醇质体的制备工艺,利用HPLC 法测定包封率,并对其进行外观粒径评价,从而制备出凝胶剂.结果:制备的醇质体粒径分布均匀,平均粒径为16.95 μm,包封率为74.70%.制得凝胶剂为半透明黏稠状胶体,平均含量为2.17 mg/10 g.结论:本实验制备工艺简单,制得的美洛昔康醇质体凝胶有很好的稳定性,具有较好的应用前景.
Abstract
Objective: To prepare Meloxicam Ethosomes Gel. Methods: The optimum preparation process of Meloxicam Ethosomes Gel was selected with orthogonal design. The rate of envelopment was determined by HPLC method. The shape, grainsize and its distribution of Meloxicam Ethosomes Gel were evaluated based on the Gel. Results: The prepared Ethosomes Gel with high encapsulation efficiency (74.70%) had narrow size distribution. The number of mean grain size was 16.95 |JLm. The Gel was translucent and ropy which was valued at 2.17 mg/10 g for its average content. Conclusion: The Meloxicam Ethosomes Gel with preferable stability is prepared with a uncomplicated technology. It is valuable with appli -cation prospect.
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