Identification of Sesquiterpenes from Kadsura coccinea and reaserch on their Nitric Oxide inhibitory activities
Objective To study the sesquiterpenes from kadsura coccinea and their nitric oxide (NO) inhibitory activities.Methods Acetone was used to extract,the compounds were isolated by semi-preparative HPLC method,their structures were identified by spectroscopy.The activated RAW 264.7 macrophages induced by LPS and IFN-γ were used to evaluate the inhibitory activities on NO production.Results Four sesquiterpenes were isolated and identified as ent-spathulenol,(-)-7βH-eudesmane-4α,11-diol,(-)-T-muurolol,(+)-cis-Calamenene.Compound 1 had strong inhibitory activity on NO production.Conclusion Compound 1-4 are obtained from the Kadsura for the first time.Compound 1 has the anti-inflammatory effect.
NETL
NSTL
万方数据
维普
