SDF-1/CXCR4轴与肿瘤转移研究进展
Research progress of SDF-1/CXCR4 axis and tumor metastasis
杨永 1于明薇 2杨国旺 2王笑民 2许炜茹2
作者信息
- 1. 北京中医药大学,北京100029
- 2. 首都医科大学附属北京中医医院肿瘤科,北京100010
- 折叠
摘要
趋化因子及其受体被认为在肿瘤转移中发挥重要作用,SDF-1及其受体CXCR4目前研究较多.CXCR4在多种高转移肿瘤中高表达,SDF-1/CXCR4轴可激活多种信号通路,参与肿瘤的侵袭与转移,可提高细胞运动、迁移与侵袭能力,促进基质降解,细胞间黏附及血管生成.提示精准干预SDF-1/CXCR4轴从而抑制肿瘤转移,具有潜在临床应用前景.
Abstract
Chemokines and their receptors are thought to play an important role in tumor metastasis.SDF-1 and its receptor CXCR4 are currently studied.CXCR4 is highly expressed in high metastatic tumors.SDF-1/CXCR4 axis can activate avariety of signaling pathways involved in tumor invasion and metastasis,which can enhance cell motility,migration and invasion ability,promote matrix degradation,cell adhesion and angiogenesis.It is suggested that the precision intervention of SDF-1/CXCR4 biological axis can inhibit tumor metastasis,which has potential clinical application prospects.
关键词
SDF-1/CXCR4/肿瘤转移/研究进展Key words
SDF-1/CXCR4/Tumor metastasis/Research progress引用本文复制引用
基金项目
国家自然科学基金(81503517)
北京市医院管理局青年人才培养“青苗”计划项目(QML20161001)
出版年
2016
NETL
NSTL
维普
万方数据