胰高血糖素样肽-2功能的研究新进展
Recent advances in the study of glucagon like peptide-2
马丽娜 1毕会民 1高凌1
作者信息
- 1. 武汉大学人民医院内分泌科,湖北武汉430060
- 折叠
摘要
胰高血糖素样肽-2 (GLP-2)是近年来发现的一种胃肠道特异性生长因子,具有多种肠道调节功能,主要包括促进肠黏膜的生长、营养物质的消化吸收、增加肠道血流量、提高肠屏障功能,并促进肠黏膜损伤的修复和愈合等.鉴于其上述功能,GLP-2在短肠综合征、炎症性肠病等多种肠道疾病中具有临床应用价值.GLP-2通过作用于胰高血糖素样肽-2受体(GLP-2R)来发挥生物学作用.最近的实验数据表明,GLP-2对糖代谢的有利影响,特别是对能量摄取增加相关的条件.本文全面概括了GLP-2的生成、分泌代谢和生理功能等方面,重点讨论了GLP-2生理功能的最新研究进展.
Abstract
Glucagon like peptide-2 (GLP-2) is a recently discovered gastrointestinal specific growth factor,with a variety of intestinal regulatory function,including:promoting growth,nutrient digestion and absorption of the intestinal mucosa,increasing intestinal blood flow,improving intestinal barrier function,and promoting the repair of intestinal mucosa damage and healing.In view of the above features,GLP-2 has clinical value in many intestinal diseases such as short bowel syndrome and inflammatory bowel disease.GLP-2 plays a biological role by acting on glucagon like peptide-2 receptors (GLP-2R).Recent experiment data suggest that GLP-2 has a beneficial effect on glucose metabolism,especially for conditions related to increased energy intake.In this paper,the generation,secretion,metabolism and physiological functions of GLP-2 are summarized,and the latest research progress of GLP-2 physiological function is discussed.
关键词
胰高血糖素样肽-2/胰高血糖素样肽-2受体/胃肠道/葡萄糖代谢Key words
Glucagon like peptide-2/Glucagon like peptide-2 receptor/Gastrointestinal tract/Glucose metabolism引用本文复制引用
基金项目
国家自然科学基金资助项目(81571376)
出版年
2017
NETL
NSTL
维普
万方数据