Important role of mitochondria-related dysfunction in heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction(HFpEF),which is now the dominant type of heart failure with highly heterogeneous clinical symptoms,poor prognosis,and growing incidence.Affected by a variety of risk factors,the pathogenesis of HFpEF is complex,the pathophysiological mechanism has not been clarified,and there is still a lack of effective treatment.In recent years,researchers have found that mitochondrial dysfunction is a potential factor in the occurrence,and development of many diseases.With the deepening of research,the important role of mitochondrial dysfunction in the occurrence and development of HFpEF is beginning to be recognized,and targeting mitochondrial dysfunction may become one of the breakthrough points in the development of treatment strategies for HFpEF.This paper reviews the research progress of mitochondrial energy metabolism,generation of reactive oxygen species,mitochondrial autophagy,regulation of calcium homeostasis,and other related functions in the pathological process of HFpEF,and briefly describes the current status of treatment of HFpEF,providing new ideas for finding new drug treatment targets and alleviating clinical symptoms of HFpEF.
Heart failure with preserved ejection fractionMitochondriaEnergy metabolismOxidative stressMitophagyCalcium homeostasis