Doxorubicin-induced cardiotoxicity(DIC)is an important factor limiting the clinical use of Doxorubicin(DOX).At present,the mechanism of DIC is not clear.There are also no effective preventive measures.Therefore,it is urgent to explore the occurrence and development of DIC from the aspects of DNA,RNA,protein,and metabolites,so as to find a new way to diagnose and prevent DIC.With the rise and development of high-throughput technologies,genomics,transcriptomics,proteomics,and metabolomics have made great progress in exploring potential biomarkers,metabolic pathways,and pathogenesis of DIC.This paper reviews the latest achievements and progress of multi-omics technology in the study of DIC,which provides a new idea for further elucidating the pathogenesis of DIC.
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