Research progress of substance P in the pathogenesis of skin derived itch-ing
The mechanism of skin derived itching is complex and currently not fully elucidated.Substance P,a neuropeptide released by sensory neuron in the skin,is an important material basis for mediate itching.This substance can can be through the substance P/neurokinin-1 receptor system and substance P/mas-related G-protein coupled receptor X2 system activation of mast cells,causing itching.Research has shown that reducing the expression of substance P in plasma and skin tissue can alleviate itching symptoms.This article discusses the relationship between substance P and skin derived itching and its role in the pathogenesis,in order to provide ideas for clinical applications and basic research in the future.
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