P物质在皮肤源性瘙痒发病机制中的研究进展
Research progress of substance P in the pathogenesis of skin derived itch-ing
金曼诗 1马铁明 2李记泉 2陈语嫣 1谢正伦1
作者信息
- 1. 辽宁中医药大学研究生学院,辽宁沈阳 110874
- 2. 辽宁中医药大学针灸推拿学院,辽宁沈阳 110874
- 折叠
摘要
皮肤源性瘙痒的发生机制较为复杂且目前尚未完全阐明.P物质是一种由皮肤感觉神经元释放的神经肽,是介导瘙痒的重要物质基础.该物质可以通过P物质/神经激肽 1受体系统、P物质/G蛋白偶联受体X2系统激活肥大细胞,从而引发瘙痒.研究表明,降低P物质在血浆及皮肤组织中的表达能够缓解瘙痒症状.本文对P物质与皮肤源性瘙痒之间的关系及其在发病机制中的作用进行论述,以期为今后临床应用及基础研究提供思路.
Abstract
The mechanism of skin derived itching is complex and currently not fully elucidated.Substance P,a neuropeptide released by sensory neuron in the skin,is an important material basis for mediate itching.This substance can can be through the substance P/neurokinin-1 receptor system and substance P/mas-related G-protein coupled receptor X2 system activation of mast cells,causing itching.Research has shown that reducing the expression of substance P in plasma and skin tissue can alleviate itching symptoms.This article discusses the relationship between substance P and skin derived itching and its role in the pathogenesis,in order to provide ideas for clinical applications and basic research in the future.
关键词
P物质/皮肤源性瘙痒/肥大细胞/研究进展Key words
Substances P/Skin derived itching/Mast cell/Research progress引用本文复制引用
基金项目
国家自然科学基金青年科学基金资助项目(82205253)
中国博士后科学基金面上资助项目(2021M693850)
辽宁省自然科学基金博士启动计划项目(2022-BS-199)
辽宁省"兴辽英才计划"项目(XLYC1902004)
出版年
2024
NETL
NSTL
万方数据