Relationship between serum levels of retinol-binding protein-4 and growth-arrest specific protein-6,and prognosis of acute myocardial in-farction patients complicated with heart failure
Objective To investigate the relationship between serum levels of retinol-binding protein-4(RBP-4)and growth arrest specific protein 6(GAS6),and prognosis of patients with acute myocardial infarction(AMI)complicated with heart failure(HF).Methods A total of 186 patients with AMI complicated with HF admitted to Tongliao City Hospital,Inner Mongolia Autonomous Region from January 2020 to January 2022 were selected and divided into poor prognosis group(61 cases)and good prognosis group(125 cases)according to 1-year follow-up.The levels of RBP-4 and GAS6 were detected by enzyme-linked immunosorbent assay.Multivariate logistic regression model was used to analyze the influencing factors of poor prognosis in AMI patients with HF,and the predictive value of serum RBP-4 and GAS6 levels in AMI patients with HF patients was analyzed by receiver operation characteristic curve.Results Age,proportion of patients with acute HF,N-terminal pro B type natriuretic peptide,and RBP-4 levels in the poor prognosis group were higher than those in the good prognosis group,while left ventricular ejection fraction and GAS6 were lower than those in the good prognosis group,the difference were statistically significant(P＜0.05).Multivariate analysis showed that age(OR=1.091,95%CI:1.016-1.173),acute HF(OR=2.468,95%CI:1.030-5.913),N-terminal pro B type natriuretic peptide(OR=1.002,95%CI:1.001-1.003),RBP-4(OR=1.156,95%CI:1.076-1.242),left ventricular ejection fraction(OR=0.829,95%CI:0.725-0.948),GAS6(OR=0.342,95%CI:0.195-0.599)were the influential factors of poor prognosis in AMI patients with HF(P＜0.05).The area under the curve of serum RBP-4 and GAS6 alone and in combination predicted poor prognosis in AMI patients with HF were 0.786,0.790,and 0.895,respectively(P＜0.05).Conclusion The increase of serum RBP-4 level and the decrease of GAS6 level are associated with poor prognosis in patients with AMI combined with HF,and the combination of the two has good predictive value for poor prognosis in patients with AMI combined with HF.
Acute myocardial infarctionHeart failureRetinol-binding protein-4Growth arrest-specific protein 6Prognosis
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