Clinical effect of Bugan Decoction combined with Dopashydrazine Tablets on the treatment of Parkinson disease
Objective To study the therapeutic effect of Bugan Decoction combined with Dopashydrazine Tablets on Parkinson disease.Methods A total of 120 Parkinson disease patients with liver-stomach disharmony were selected from the outpatient and ward of the First Department of Encephalopathy,Dongzhimen Hospital Beijing University of Chinese Medicine from January 2018 to May 2022.They were divided into western medicine group,Chinese medicine group,and combination group,with 40 cases in each group.Western medicine group was treated with Dopashydrazine Tablets,while the Chinese medicine group was treated with Bugan Decoction,and the combination group was treated with Dopashydrazine Tablets combined and Bugan Decoction,the treatment lasted for eight weeks.The 39-item Parkinson disease quality of life questionnaire(PDQ-39),unified Parkinson disease rating scale(UPDRS),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)among three groups were compared before treatment,four weeks after treatment,and eight weeks after treatment;traditional Chinese medicine symptoms curative effect among three groups were compared;the incidence of adverse reactions among three groups were observed.Results Overall comparison:there were significant differences in PDQ-39 and UPDRS scores between groups,time,and interaction between western medicine group and combined group,Chinese medicine group and combination group(P＜0.05).Intra-group comparison:after four and eight weeks of treatment,PDQ-39 and UPDRS scores in three groups were lower than those before treatment(P＜0.05).Comparison between groups:after four and eight weeks of treatment,POQ-39 scores in combined groups were lower than those in western medicine group and Chinese medicine group(P＜0.05).After four weeks of treatment,UPDRS scores in combined group were higher than those in western medicine group and Chinese medicine group(P＜0.05);after eight weeks of treatment,UPDRS scores in combination group were lower than those in western medicine group and Chinese medicine group(P＜0.05).Overall comparison:there were significant differences in the levels of IL-6 and TNF-α between groups,time,and interaction between western medicine group and combined group,Chinese medicine group and combination group(P＜0.05).Intra-group comparison:after four and eight weeks of treatment,the levels of IL-6 and TNF-α in three groups were lower than those before treatment(P＜0.05);inter-group comparison:after four and eight weeks of treatment,the levels of IL-6 and TNF-α in combined group were lower than those in western medicine group and Chinese medicine group(P＜0.05).The clinical curative effect of combined group was better than that of western medicine group and Chinese medicine group(P＜0.05).No adverse reactions occurred in Chinese medicine group,there was no significant difference in the total incidence of adverse reactions between the western medicine group and combined group(P＞0.05).Conclusion Bugan Decoction combined with Dopashydrazine Tablets has a good therapeutic effect on Parkinson disease,and can be used as a new therapeutic idea to treat Parkinson disease.
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