Analysis of influencing factors of poor prognosis of senile early non-small cell lung cancer after percutaneous microwave coagulation therapy
Objective To analyze the influencing factors of poor prognosis after percutaneous microwave coagulation therapy(PMCT).Methods A total of 85 elderly patients with early non-small cell lung cancer(NSCLC)were selected from January 2019 to January 2022 in the First People's Hospital of Xuzhou,Jiangsu Province,including seven cases of ablative cancer.A total of 78 patients were enrolled to receive PMCT treatment,followed up for six months,and divided into good prognosis group and poor prognosis group according to the efficacy.Clinical data of the two groups were collected and compared.including gender,age,preoperative lung function(vital capacity[VC],forced vital capacity[FVC],forced expiratory volume in the first second[FEV1],maximum large volume of air volume[MVV]),systemic immuno-inflammatory nutrition index(SII),tumor primary location,pathological classification,pathological stage,lesion diameter,degree of differentiation,and postoperative chemotherapy.Multivariate logistic regression analysis was used to identify the risk factors for poor prognosis of early senile NSCLC treated with PMCT.Results There were 69 cases with good prognosis and 9 cases with poor prognosis.The age of the poor prognosis group＞70 years old,the SII＞500,the pathological stageⅡ,the lesion diameter＞4 cm,the low degree of differentiation,the proportion of postoperative chemotherapy were higher than that of the good prognosis group,and the level of FEV1 was lower than that of the good prognosis group,and the differences were statistically significant(P＜0.05).Multivariate logistic regression analysis showed that age＞70 years old(OR=2.145,95%CI=1.143-4.025),FEV1＜81.67 L(OR=2.592,95%CI=1.263-5.319),SII＞500(OR=2.168,95%CI=1.250-3.760),pathological stageⅡ(OR=3.421,95%CI=1.064-10.999),lesion diameter＞4 cm(OR=2.538,95%CI=1.056-6.100),low differentiation(OR= 2.563,95%CI=1.243-5.285),and no chemotherapy(OR=3.156,95%CI=1.319-7.551)were the risk factors for poor prognosis after PMCT treatment(P＜0.05).Conclusion Age,FEV1,SII,pathological stage,lesion diameter,differentiation degree,and whether to receive chemotherapy after PMCT treatment are the factors affecting the poor prognosis of patients after treatment,which can be used to predict the prognosis of patients after treatment.
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