Clinical efficacy and influence of oxidative stress of single-,two-,and three-port thoracoscopic lobectomy in elderly patients with early-stage non-small cell lung cancer
Objective To investigate the clinical efficacy and influence of oxidative stress of single-,two-,and three-port thoracoscopic lobectomy in elderly patients with early-stage non-small cell lung cancer.Methods A total of 89 elderly patients with early-stage non-small cell lung cancer admitted to Haian Hospital of Traditional Chinese Medicine,Jiangsu Province from July 2019 to July 2022 were included in this study.They were divided into single-port group(30 cases),two-port group(30 cases),and three-port group(29 cases)by random number table method.Lobotomy was performed by single-,two-,and three-port thoracoscopy,respectively.Perioperative indexes of the three groups were recorded and compared,pain degree of the three groups was assessed by visual analogue scale(VAS)one day after surgery,and lung function levels(forced vital capacity[FVC]and forced expiratory volume in one second[FEV 1])of the three groups were detected and compared before and three months after surgery.The levels of oxidative stress indexes(epinephrine[E],nore-pinephrine[NE],and cortisol[Cor])before and one day after operation were detected and compared among the three groups,and the occurrence of complications in the three groups were recorded.Results The operation time of the three-port group was longer than that of the single-port and two-port groups,and the VAS score on the first day after operation was higher than that of the single-port and two-port groups(P＜0.05).Three months after operation,FVC and FEV1 in the three groups were higher than those before operation,FVC and FEV 1 in the three-port group were lower than those in the single-port group,and FEV 1 was lower than that in the two-port group(P＜0.05).On the first day after surgery,the levels of E,NE,and Cor in the three groups were higher than before suregry,the levels of E,NE,and Cor in the two-port and three-port groups were higher than those in the single-port group,and those in the three-port group were higher than those in the two-port group(P＜0.05).The complication rate of the three-port group was higher than that of the single-port group(P＜0.05).Conclusion The efficacy of single-port thoracoscopic lobectomy is comparable to that of two-port thoracoscopic lobectomy,and single-port thoracoscopic lobectomy can effectively reduce the postoperative stress level of patients with high safety.
Non small cell lung cancerElderlyThoracoscopeOxidative stress
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