中国医药导报2024,Vol.21Issue(3) :60-63.DOI:10.20047/j.issn1673-7210.2024.03.11

非预期卵巢低反应患者的影响因素及个体化治疗的研究进展

Research progress on influencing factors of patients with unexpected poor ovarian response and individualized treatment

马明男 朱霞 李慧珍 赵雨恒 黄炜瑜 马天仲
中国医药导报2024,Vol.21Issue(3) :60-63.DOI:10.20047/j.issn1673-7210.2024.03.11

非预期卵巢低反应患者的影响因素及个体化治疗的研究进展

Research progress on influencing factors of patients with unexpected poor ovarian response and individualized treatment

马明男 1朱霞 1李慧珍 1赵雨恒 1黄炜瑜 1马天仲1
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作者信息

  • 1. 广东医科大学附属医院生殖医学中心,广东湛江 524001
  • 折叠

摘要

目前针对非预期卵巢低反应(POR)的治疗策略侧重于获取更多的卵母细胞,而波塞冬标准的提出至少获取 1 个可移植的整倍体胚胎,成为辅助生殖技术成功的新指标,因此将仅有的卵母细胞培育成优质胚胎是此类患者治疗的重要方面.本文重点阐述影响非预期POR的相关因素及其获取优质胚胎个体化治疗相关的 7 个措施:扳机日卵泡大小、双扳机方案、人工卵母细胞激活、囊胚移植、植入前非整倍体检测、时差成像、生物工程技术的应用.

Abstract

Current treatment strategies for unexpected poor ovarian response(POR)focus on obtaining more oocytes,and the POSEIDON standard proposes to obtain at least one transplantable euploid embryo,it has become a new indicator of the success of assisted reproductive technology,so growing the only oocytes into high-quality embryos is an important aspect of the treatment of such patients.This paper focuses on the related factors affecting unexpected POR and seven measures related to obtaining high-quality embryo individualized treatment:trigger day follicle size,double trigger protocol,artificial oocyte activation,blastocyst transfer,preimplantation genetic testing for aneuploidy,time-lapse imaging,application of bioengineering techniques.

关键词

波塞冬标准/非预期卵巢低反应/胚胎质量/个体化治疗

Key words

POSEIDON/Unexpected poor ovarian response/Eembryo quality/Individualized treatment

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基金项目

广东省基础与应用基础研究自然科学基金项目(2022A1515010849)

出版年

2024
中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
参考文献量32
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