首页|非预期卵巢低反应患者的影响因素及个体化治疗的研究进展

非预期卵巢低反应患者的影响因素及个体化治疗的研究进展

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目前针对非预期卵巢低反应(POR)的治疗策略侧重于获取更多的卵母细胞,而波塞冬标准的提出至少获取 1 个可移植的整倍体胚胎,成为辅助生殖技术成功的新指标,因此将仅有的卵母细胞培育成优质胚胎是此类患者治疗的重要方面.本文重点阐述影响非预期POR的相关因素及其获取优质胚胎个体化治疗相关的 7 个措施:扳机日卵泡大小、双扳机方案、人工卵母细胞激活、囊胚移植、植入前非整倍体检测、时差成像、生物工程技术的应用.
Research progress on influencing factors of patients with unexpected poor ovarian response and individualized treatment
Current treatment strategies for unexpected poor ovarian response(POR)focus on obtaining more oocytes,and the POSEIDON standard proposes to obtain at least one transplantable euploid embryo,it has become a new indicator of the success of assisted reproductive technology,so growing the only oocytes into high-quality embryos is an important aspect of the treatment of such patients.This paper focuses on the related factors affecting unexpected POR and seven measures related to obtaining high-quality embryo individualized treatment:trigger day follicle size,double trigger protocol,artificial oocyte activation,blastocyst transfer,preimplantation genetic testing for aneuploidy,time-lapse imaging,application of bioengineering techniques.

POSEIDONUnexpected poor ovarian responseEembryo qualityIndividualized treatment

马明男、朱霞、李慧珍、赵雨恒、黄炜瑜、马天仲

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广东医科大学附属医院生殖医学中心,广东湛江 524001

波塞冬标准 非预期卵巢低反应 胚胎质量 个体化治疗

广东省基础与应用基础研究自然科学基金项目

2022A1515010849

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(3)
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