Research progress of intestinal microbiotherapy on intervention autism spectrum disorder
Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder and the prevalence has been increasing.In addition to symptoms of impaired communication,behaviors,and social interaction,most of children patients are accompanied by different degrees of gastrointestinal symptoms.At present,the pathological mechanism of ASD is still unclear,with the in-depth study of intestinal microflora,it has been found that symptoms in children patients with ASD are closely related to intestinal microbiota.Therefore,regulation of intestinal microflora have become one of the hot spots in prevention and treatment of ASD.Based on the impact of intestinal microflora on ASD,this paper reviews the mechanism and effect of"brain-gut axis"through intestinal microbial(probiotics,prebiotics,and fecal microbiota transplantation)intervention on ASD,aiming to provide new theoretical basis and new ideas for the pathogenesis and clinical treatment of ASD.