Study on immunosuppressive effect of bone marrow-derived suppressor cells in trauma induced inflammatory response
Traumatic stress can lead to an excessive systemic inflammatory response in the host,which occurs as a result of an uncontrolled response to infection,while later multiple mechanisms can lead to a suppressed immune function,which increases the risk of sepsis,multiple organ failure,and death.The immunosuppressive mechanism can regulate the host to clear antigens while preventing secondary tissue damage and promoting tissue repair.As one of the main active cells mediating immunosuppression,myeloid derived suppressor cells from bone marrow play different roles in different pathophysiological periods,and their main function is to promote tissue repair and wound healing in the early stage of trauma.Long-term trauma may lead to persistent inflammation,immunosuppression,and catabolic syndrome.Based on the different pathophysiological stages of immunoinflammatory response after multiple trauma,this paper explores the positive and negative effects of the immunosuppressive mechanism mediated by the temporary activation of myeloid derived suppressor cells in the early stage and the continuous pathological activation in the later stage on the disease and outcome.
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