Effects of Dipyridamole and low molecular weight heparin on coagulation function,renal function,endothelial function,and β2-glycoproteinⅠ/oxi-dized low-density lipoprotein complex in children with nephrotic syn-drome
Objective To investigate the effects of Dipyridamole and low molecular weight heparin on coagulation function,renal function,endothelial function,and β2-glycoproteinⅠ(β2-GPⅠ)/oxidized low-density lipoprotein(ox-LDL)complex in children with nephrotic syndrome.Methods Ninety children patients with nephrotic syndrome admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine from April 2021 to June 2022 were selected and they were divided into control group A(30 cases),control group B(30 cases),and observation group(30 cases)by random number table method.Control group A was given Methylprednisolone+low molecular weight heparin treatment,control group B was given Methylprednisolone+Dipyridamole treatment,observation group was given Methylprednisolone+low molecular weight heparin+Dipyridamole treatment,all three groups were treated continuously for 30 days.The treatment effects of three groups were compared;the coagulation function indexes(prothrombin time[PT],activated partial thromboplastin time[APTT],fibrinogen[FIB],and D-dimer[DD]),kidney function indexes(urea nitrogen[BUN],cystatin C[CysC],serum creatinine[Scr],and 24-hour urine protein quantification),and endothelial function indexes(endothelin-1[ET-1],von Willebrand factor[vWF]),and β2-GPⅠ/ox-LDL complex were compared;the occurrence of adverse reactions in three groups was observed.Results There was no significant difference between observation group and control group A(P＞0.05);the curative effect of observation group was better than that of control group B(P＜0.05).After treatment,APTT and PT in observation group were longer than those in control group A and control group B(P＜0.05),while the levels of D-D,FIB,BUN,CysC,Scr,24-hour urine protein quantification,ET-1,vWF,β2-GPⅠ/ox-LDL complex were lower than those of control group A and control group B(P＜0.05).There was no significant difference in the total incidence of adverse reactions between observation group and control group A(P＞0.05);there was no significant difference in the total incidence of adverse reactions between observation group and control group B(P＞0.05).Conclusion Dipyridamole combined with low molecular weight heparin can improve the clinical efficacy,coagulation function,and renal function in children with nephrotic syndrome,and has high safety.
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