Effect and safety of estrogen combined with Dydrogesterone in the treat-ment of ovulatory dysfunction abnormal uterine bleeding during gesta-tional age
Objective To study the effect and safety of estrogen combined with Dydrogesterone in the treatment of ovulatory dysfunction abnormal uterine bleeding during gestational age.Methods A total of 192 patients with ovulatory dysfunction abnormal uterine bleeding during gestational age of the Affiliated Shuyang Hospital of Xuzhou Medical University from February 2020 to February 2021 were selected,and they were divided into single drug group and combined group according to random number table method,with 96 cases in each group.The single drug group was treated with Dydrogesterone,and the combined group was treated with estrogen combined with Dydrogesterone,both groups were treated for three months.The clinical effect and hemostasis of two groups were compared;the menstrual cycle,menstrual duration,endometrial thickness,and sex hormone levels(follicle stimulating hormone[FSH],luteinizing hormone[LH],estradiol[E 2])before and after treatment were compared between two groups;and the occurrence of adverse reactions were recorded.Results The clinical efficacy in combined group was better than that in single drug group(P＜0.05).The bleeding control time and complete hemostasis time in combined group were shorter than those in single drug group(P＜0.05).After treatment,the menstrual cycle,menstrual duration were shorter than those before treatment,and the combined group was shorter than single drug group(P＜0.05);the endometrial thickness and the levels of FSH,LH,and E2 in two groups were lower than those before treatment,and the combined group was lower than single drug group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P＞0.05).Conclusion Estrogen combined with Dydrogesterone is effective in the treatment of ovulatory dysfunction abnormal uterine bleeding during gestational age.It can improve hemostasis,regulate menstrual cycle,menstrual duration,and endometrial thickness,reduce the level of sex hormones,and has high safety.
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