Clinical efficacy of Duhuo Jisheng Decoction combined with Chitinose on knee osteoarthritis with cold and damp obstruction
Objective To observe the clinical effect of Duhuo Jisheng Decoction combined with Chitinose in treating knee osteoarthritis with cold and damp obstruction.Methods From January to August 2023,60 patients with knee osteoarthritis in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were selected,and they were divided into observation group and control group by random number table method,with 30 cases in each group each.The observation group was treated with Duhuo Jisheng Decoction(decocted with water,200 ml/dose,once a day,twice warm in the morning and evening)combined with Chitosan Injection(2 ml/time,once a week,for three weeks),while the control group was treated with Loxoprofen Sodium Tablets(120 mg each time,three times a day)combined with Chitosan Injection(2 ml/time,once a week,for three weeks)treatment.The therapeutic effectiveness of the two groups was evaluated.Traditional Chinese medicine symptom score,the western Ontario and McMaster Universities osteoarthritis index score(WOMAC score),visual analogue scale(VAS)score,and serum interleukin-1(IL-1),tumor necrosis factor-α(TNF-α),cyclooxygenase(COX-2)and prostaglandin(PGE2)levels were compared between the two groups before and after treatment,patients in both groups were followed up by telephone at six weeks after treatment to observe the recurrence rate.Results The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,VAS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).After treatment,WOMAC scores in both groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of IL-1 and TNF-α in both groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).After treatment,the serum COX-2 and PGE2 of the two groups were significantly decreased,and the serum COX-2 and PGE 2 of the observation group were significantly lower than those of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in recurrence rate between the two groups(P＞0.05).Conclusion Duhuojisheng Decoction combined with Chitose Injection can significantly improve the clinical symptoms of knee osteoarthritis,restore the function of knee joint and improve the quality of life.
万方数据
维普
