Research progress on the mechanism of ferroptosis in gliomas and the use of traditional Chinese medicine monomers to induce ferroptosis in glioma cells
Research progress on the mechanism of ferroptosis in gliomas and the use of traditional Chinese medicine monomers to induce ferroptosis in glioma cells
Glioma is the most common malignant tumor of the nervous system.The current therapeutic effect is not satisfactory,and it is urgent to find new therapeutic methods.Ferroptosis is closely related to the occurrence and development,treatment and drug resistance of glioma.Some traditional Chinese medicine monomers can induce ferroptosis in glioma cells,provide new ideas for the treatment of glioma.This article elaborates on the specific mechanisms and related research progress of iron metabolism,lipid metabolism,xCT-GPX4 pathway,etc.in the process of ferroptosis in glioma cells.It summarizes nine traditional Chinese medicine monomers that have been proven to induce ferroptosis in glioma cells and their specific mechanisms of action.It aims to provide reference and theoretical basis for the treatment of glioma with traditional Chinese medicine.
关键词
1胶质瘤/中药单体/铁死亡/机制
Key words
Glioma/Chinese medicine monomers/Ferroptosis/Mechanism
维普
万方数据