Effect of"Tianlongjie"treatment scheme on pulmonary function and serum krebs von den lungen-6 and chemokine cc-motif ligand 18 in patients with advanced idiopathic pulmonary fibrosis
Objective To evaluate the effect of"Tianlongjie"treatment scheme on pulmonary function and serum krebs von den lungen-6(KL-6)and chemokine cc-motif ligand 18(CCL18)in patients with advanced idiopathic pulmonary fibrosis(IPF).Methods A randomized,double-blind,double-dummy controlled clinical trial was conducted,a total of 36 patients with advanced IPF,which were all from the Department of Pulmonary Critical Care Medicine,the Third Affiliated Hospital of Yunnan University of Chinese Medicine were divided into the experimental group and the control group with the method of simple randomization,with 18 cases in each group.The experimental group was treated with Tianlongjie,while the control group was treated with Pirfenidone,the course of treatment was three months.Pulmonary function index,including total lung capacity(TLC),tidal volume(TV),and diffusion capacity of carbon monoxide(DLCO),serum KL-6 and CCL18 level were observed before and after treatment.Before and after treatment patients were scored by high resolution CT.Safety indexes were observed.Results After treatment,there was no statistical significance in TLC and TV between the two groups compared with before treatment and between the two groups(P＞0.05),DLCO between the two groups was higher than those before treatment,and the experiment group was higher than the control group,the differences were statistically significant(P＜0.05).After treatment,there was no significant difference in HRCT score in the two groups compared with before treatment and between the two groups(P＞0.05).After treatment,the levels of serum KL-6 and CCL18 in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in serum KL-6 and CCL18 levels between the two groups before and after treatment(P＞0.05).In the course of treatment,there were no adverse reactions in both groups.Conclusion"Tianlongjie"treatment scheme improved lung function to some extent in advanced IPF.And the scheme stabilized the condition by regulating inflammatory response.The scheme is safe and reliable in the treatment of IPF.
Idiopathic pulmonary fibrosisTianlongjiePulmonary functionKrebs von den Lungen-6Chemokine cc-motif ligand 18
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