Relationship between anti-mitochondrial antibodies,erythrocyte volume distribution width,and response to Ursodeoxycholic Acid therapy in pri-mary biliary cholangitis
Objective To investigate the relationship between anti-mitochondrial antibody(AMA),erythrocyte distribution width(RDW),and Ursodeoxycholic Acid therapy in patients with primary biliary cholangitis.Methods A retrospective study was conducted to select 126 patients with primary biliary cholangitis received Ursodeoxycholic Acid therapy in Nanjing Gaochun People's Hospital from June 2019 to June 2022.According to the treatment response outcome,the patients were divided into good response group(60 cases)and poor response group(66 cases).Clinical data,and AMA,RDW levels before treatment were compared between the two groups.The effects of AMA and RDW on Ursodeoxycholic Acid response in patients with primary biliary cholangitis were analyzed by logistic regression model.Results The levels of glutamic-pyruvic transaminase(GPT),glutamic oxalic aminotransferase(GOT),alkaline phosphatase,γ-glutamyl transferase(GGT),total bilirubin(TBil),direct bilirubin(DBil),and RDW in poor response group were higher than those in good response group before treatment,and the positive rate of AMA was lower than that in good response group,the differences were statistically significant(P＜0.05).The results of multivariate analysis showed that GPT(OR=1.941,95％CI:1.157-3.256),GOT(OR=1.808,95％CI:1.073-3.045),GGT(OR=1.504,95％CI:1.028-2.200),TBil(OR=2.088,95％CI:1.279-3.408),DBil(OR=1.735,95％CI:1.112-2.707),RDW(OR=1.562,95％CI:1.091-2.236),and AMA positive rate(OR=0.584,95％CI:0.399-0.854)were independent factors of poor response to Ursodeoxycholic Acid therapy in patients with primary biliary cholangitis(P＜0.05).Conclusion Increased RDW and decreased AMA positive rate are independent risk factors for poor response to Ursodeoxycholic Acid therapy in patients with primary biliary cholangitis,which should be paid attention to in clinic.
Anti-mitochondrial antibodiesRed blood cell distribution widthPrimary biliary cholangitisResponse effect
万方数据
维普
