摘要
脓毒症相关性脑病(SAE)是一种继发于脓毒血症的中枢神经系统并发症,其病情凶险、预后不良、病死率高、并发症多,发病机制十分复杂,具体病因尚不明确.越来越多的研究发现血脑屏障破坏、小胶质细胞激活、线粒体功能障碍、细胞凋亡、炎症反应和氧化应激等诸多因素与SAE的发生发展密切相关.深入理解这些机制有助于早期诊断和干预,提高患者生存率和生活质量.在现有的基础上,本文通过查阅国内外相关文献资料,对SAE发病机制的研究进展进行综述.
Abstract
Sepsis associated encephalopathy(SAE)is a complication of central nervous system secondary to sepsis.It is dangerous,has a poor prognosis,high mortality and many complications.Its pathogenesis is very complex,the specific etiology is still unclear.More and more studies have found that many factors,such as destruction of blood-brain barrier,activation of microglia,mitochondrial dysfunction,apoptosis,inflammatory reaction,and oxidative stress,are closely related to the occurrence and development of SAE.A deeper understanding of these mechanisms can help in early diagnosis and intervention,improving patient survival and quality of life.On the basis of the existing literature,this paper reviewed the research progress of SAE pathogenesis by referring to the relevant literatures at home and abroad.
基金项目
云南省教育厅科学研究基金项目(2023Y0966)
维普
万方数据