Expression and clinical detection value of brain natriuretic peptide,an-giotensin Ⅱ,and plasma protein C in elderly patients with coronary heart disease
Objective To investigate the expression and clinical value of brain natriuretic peptide,angiotensin Ⅱ,and plasma protein C(BNP),(Ang Ⅱ)and plasma protein C(PC)in elderly patients with coronary heart disease.Methods A total of 78 elderly patients with coronary heart disease diagnosed by coronary angiography in Cangzhou People's Hospital of Hebei Province from January 2021 to January 2023 were selected as the study group.Among them,27 cases with stable angina pectoris.31 cases with unstable angina pectoris,20 cases with myocardial infarction.Stable angina pectoris presents with ST segment depression.In unstable angina pectoris,the transient ST segment depression of ECG was more than 1 mm,which recovered or was close to normal after remission,and the markers of myocardial damage were not significantly increased.The myocardial infarction was characterized by persistent chest pain＞30 min and dynamic electrocardiogram changes with typical myocardial injury and necrosis.Then 60 healthy people were selected as control group.The clinical data,levels of BNP,Ang Ⅱ,PC,and clinical detection value of the two groups were compared.Results The levels of BNP and Ang Ⅱ in the study group were higher than those in the control group,and the level of PC was lower than that in the control group,the differences were statistically significant(P＜0.05).BNP and Ang Ⅱ levels in myocardial infarction group were higher than those in stable angina pectoris and unstable angina pectoris groups,and PC levels were significantly lower than those in stable angina pectoris and unstable angina pectoris groups,the differences were statistically significant(P＜0.05).In elderly patients with coronary heart disease,BNP was positively correlated with Ang Ⅱ(r＞0,P＜0.05),BNP was negatively correlated with PC(r＜0,P＜0.05),and Ang Ⅱ was negatively correlated with coronary heart disease in the elderly PC(r＜0,P＜0.05).The sensitivity,specificity and accuracy of the three combined tests were higher than that of BNP,Ang Ⅱ and PC,and the detection rate of elderly patients with coronary heart disease was higher.Conclusion The expression of BNP,Ang Ⅱ,and PC in the elderly coronary heart disease is obvious,BNP,Ang Ⅱ,and PC as the clinical diagnosis of coronary heart disease has a certain effect,worthy of clinical application.
Elderly coronary heart diseaseBrain natriuretic peptideAngiotensin ⅡBlood protein C
万方数据
维普
