Analysis on the effect and influencing factors of anticoagulant therapy in patients with atrial fibrillation in a hospital
Objective To analyze the status of anticoagulation therapy in patients with atrial fibrillation in Daxing District People's Hospital of Beijing.Methods Retrospective analysis was used to analyze 162 patients with atrial fibrillation in Daxing District People's Hospital of Beijing from January to December 2021,and the anticoagulation status of follow-up patients was divided into effective anticoagulation group(117 cases)and ineffective anticoagulation group(45 cases).The data of the two groups were compared to identify the factors related to the failure of anticoagulant therapy in patients with atrial fibrillation.Results There were statistically significant differences in age,sex,smoking ratio,the proportion of users of β-blockers,diuretics,antihypertensive drugs,lipid-regulating drugs,nitrates,and hemostatic drugs,cardiac insufficiency ratio,radiofrequency ablation ratio,persistent atrial fibrillation ratio admission heart rate,alanine aminotransferase,aspartate aminotransferase,thrombin time,prothrombin time,activated partial thromboplastin time,and international standardized ratio level of the two groups(P＜0.05).The proportion of NSAIDS,tumor proportion,platelet count,prothrombin activity,fibrinogen and D-dimer in anticoagulant effective group we re lower than those in anticoagulant ineffective group;the duration of hospitalization was shorter than that of anticoagulant ineffective group,and the differences were statistically significant(P＜0.05).Logistic regression analysis results showed that age ≥ 65 years(OR=6.206,95％ CI=1.342-28.698),persistent atrial fibrillation(OR=1.737,95％ CI=2.397-4.184),D-dimer＜0.5 mg/L(OR=4.659,95％ CI=1.590-13.649)were influencing factors for the efficacy of anticoagulation therapy in patients with atrial fibrillation(P＜0.05).Conclusion The anticoagulation rate of patients with atrial fibrillation in Daxing District People's Hospital of Beijing is better.The elderly patients with persistent atrial fibrillation and high-risk patients with low D-dimer level should be monitored,and the anticoagulation program should be adjusted in time to improve the anticoagulation effect.
万方数据
维普
