Application value of different platelet concentrations to guide dual antiplatelet therapy in patients with mild ischemic stroke/transient ischemic attack
Objective To explore the efficacy and safety of dual antiplatelet regimen guided by different platelet concentr-ations in the treatment of patients with mild ischemic stroke(MIS)/transient ischemic attack(TIA).Methods A total of 180 cases of MIS/TIA patients admitted to Wujin Hospital of Traditional Chinese Medicine of Changzhou,Jiangsu Province from September 2020 to May 2022 were selected as the research objects.They were divided into control group and experimental group,with 90 cases in each group.The control group received Aspirin+Clopidogrel;experimental group was adm-inistered according to platelet concentration.After three months of treatment,the recurrence rate,incidence of symptomatic intracranial hemorrhage,and mortality were compared between two groups;the National Institutes of Health stroke scale(NIHSS)scores of two groups were compared before treatment,three weeks and three months after treatment;the platelet count of two groups were compared before treatment,seven days,and three months after treatment;the occurrence of adverse reactions during treatment was observed.Results During the treatment period,seven patients in control group withdrew from the study due to personal reasons,resulting in a final enrollment of 83 cases;in study group,six patients withdrew from the study due to personal reasons,resulting in a final enrollment of 84 cases.No death occurred in both groups;the recurrence rate of experimental group was higher than that of control group,and the symptomatic intracranial hemorrhage rate was lower than that of control group(P＜0.05).Overall analysis:the platelet count time before treatment,seven days,and three months after treatment between two groups had statistical significances(P＜0.05);there were no significant difference in platelet count between two groups before treatment,seven days,and three months after treatment(P＞0.05).Intra-group comparison:pairwise comparison of platelet count at different time points between two groups showed statistically significant differences(P＜0.05).Comparison between the two groups:before treatment,seven days,and three months after treatment,there were no significant differences in platelet count between two groups(P＞0.05).Overall analysis:before treatment,three weeks,and three months after treatment,the differences in NIHSS score time between two groups were statistically significant(P＜0.05).There were no significant differences in NIHSS scores between two groups before treatment,three weeks,and three months after treatment(P＞0.05).Intra-group comparison:the NIHSS scores of two groups was pairwise compared at different time points,and the differences were statistically significant(P＜0.05).Comparison between groups:there were no significant differences in NIHSS scores between two groups before treatment,three weeks,and three months after treatment(P＞0.05).There were no significant differences in the incidence of skin,mucous ecchymosis,gingival and nasal bleeding and gastrointestinal reaction between two groups(P＞0.05).Conclusion Different platelet concentrations guide the application of dual antiplatelet regimen in MIS/TIA patients,which helps to reduce the rate of intracranial hemorrhage,but the risk of recurrence is increased.
万方数据
维普
